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排序方式: 共有6513条查询结果,搜索用时 265 毫秒
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Patel PS Forouhi NG Kuijsten A Schulze MB van Woudenbergh GJ Ardanaz E Amiano P Arriola L Balkau B Barricarte A Beulens JW Boeing H Buijsse B Crowe FL de Lauzon-Guillan B Fagherazzi G Franks PW Gonzalez C Grioni S Halkjaer J Huerta JM Key TJ Kühn T Masala G Nilsson P Overvad K Panico S Quirós JR Rolandsson O Sacerdote C Sánchez MJ Schmidt EB Slimani N Spijkerman AM Teucher B Tjonneland A Tormo MJ Tumino R van der A DL van der Schouw YT Sharp SJ Langenberg C Feskens EJ Riboli E 《The American journal of clinical nutrition》2012,95(6):1445-1453
64.
Effect of B-vitamins and n-3 PUFA supplementation for 5 years on blood pressure in patients with CVD
Szabo de Edelenyi F Vergnaud AC Ahluwalia N Julia C Hercberg S Blacher J Galan P 《The British journal of nutrition》2012,107(6):921-927
Certain epidemiological and experimental studies suggest that n-3 fatty acids and folate can reduce blood pressure (BP). We investigated the effect of a daily supplementation with dietary doses of B-vitamins or n-3 fatty acids for 5 years on BP in patients with a history of CVD who participated in the Supplémentation en Folates et Omega-3 trial. The patients (n 2501; 1987 men and 514 women) were randomly assigned in a 2 × 2 factorial design to one of four groups: B-vitamins (5-methyl-THF (560 μg); vitamin B? (3 mg) and vitamin B?? (20 μg)) and a placebo capsule for n-3 fatty acids; n-3 fatty acids (600 mg of EPA and DHA at a ratio of 2:1) and a placebo capsule for B-vitamins; both B-vitamins and n-3 fatty acids; or placebo capsules for both treatments. The patients took two capsules daily in a double-blind manner for a median duration of 4·7 years. At baseline and annual examination for 5 years, the patients underwent a clinical examination where BP and clinical and biological parameters were assessed. No effect of supplementation with either n-3 PUFA or B-vitamins on BP was observed in crude and adjusted multivariate models. Change in BP was not associated with change in homocysteine. In conclusion, the present results do not support the routine use of dietary supplements containing B-vitamins, or of n-3 fatty acids, to reduce BP in people with prior CVD. 相似文献
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Chatzi L Mendez M Garcia R Roumeliotaki T Ibarluzea J Tardón A Amiano P Lertxundi A Iñiguez C Vioque J Kogevinas M Sunyer J;INMA RHEA study groups 《The British journal of nutrition》2012,107(1):135-145
Dietary intake of specific nutrients or food groups during pregnancy could influence fetal growth, but scant evidence is available on effects of dietary patterns. The aim of this study was to evaluate the impact of Mediterranean diet (MD) adherence during pregnancy on fetal growth in two population-based mother-child cohorts in Spain and Greece. We studied 2461 mother-newborn pairs from the Spanish multi-centre 'INMA' study (Atlantic area: INMA-Atlantic; Mediterranean area: INMA-Mediterranean), and 889 pairs from the 'RHEA' study in Crete, Greece. Maternal diet during pregnancy was assessed by FFQ and MD adherence was evaluated through an a priori score. Fetal growth restriction was based on a customised model, and multivariate log-binomial and linear regression models were used to adjust for several confounders. MD scores differ significantly between the cohorts with women in INMA-Atlantic reporting higher intakes of fish and dairy products, while women in the Mediterranean area reported higher intakes of cereals, vegetables and fruits. Women with high MD adherence had a significantly lower risk of delivering a fetal growth-restricted infant for weight (risk ratios: 0·5; 95?% CI 0·3, 0·9) in the INMA-Mediterranean cohort. Stratified analysis by smoking revealed that higher MD adherence increased birth weight and birth length in smoking mothers, whereas this effect was not apparent in non-smoking mothers. The results of the present study show that several types of MD exist across European Mediterranean regions. High MD adherence may modify the detrimental effect of smoking on birth size, but overall effects of diet were not universal for the studies in this analysis. 相似文献
66.
Emilia Gómez-Hoyos Ana Ortolá Buigues Maria Dolores Ballesteros Pomar Alfonso Vidal Casariego Yaiza García Delgado Maria Julia Ocón Bretón Angel Luis Abad González Luis Miguel Luengo Pérez Pilar Matía Martín Maria José Tapia Guerrero María Dolores Del Olmo García Ana Herrero Ruiz Julia Álvarez Hernández Diego Bellido Guerrero Sandra Herranz Antolín Carmen Tenorio-Jiménez Maria Victoria García Zafra Francisco Botella Romero Daniel De Luis Román 《Clinical nutrition (Edinburgh, Scotland)》2019,38(6):2639-2644
67.
Iris?Iglesia Isabelle?Guelinckx Pilar?M.?De?Miguel-Etayo Esther?M.?González-Gil Jordi?Salas-Salvadó Stavros?A.?Kavouras Joan?Gandy Homero?Martínez Saptawati?Bardosono Morteza?Abdollahi Esmat?Nasseri Agnieszka?Jarosz Guansheng?Ma Esteban?Carmuega Isabelle?Thiébaut Luis?A.?MorenoEmail author 《European journal of nutrition》2015,54(2):57-67
Purpose
To describe total fluid intake (TFI) according to socio-demographic characteristics in children and adolescents worldwide.Methods
Data of 3611 children (4–9 years) and 8109 adolescents (10–18 years) were retrieved from 13 cross-sectional surveys (47 % males). In three countries, school classes were randomly recruited with stratified cluster sampling design. In the other countries, participants were randomly recruited based on a quota method. TFI (drinking water and beverages of all kinds) was obtained with a fluid-specific record over 7 consecutive days. Adequacy was assessed by comparing TFI to 80 % of adequate intake (AI) for total water intake set by European Food Safety Authority. Data on height, weight and socio-economic level were collected in most countries.Results
The mean (SD) TFI ranged from [1.32 (0.68)] to [1.35 (0.71)] L/day. Non-adherence to AIs for fluids ranged from 10 % (Uruguay) to >90 % (Belgium). Females were more likely to meet the AIs for fluids than males (4–9 years: 28 %, OR 0.72, p = 0.002; 10–18 years: 20 %, OR 0.80, p = 0.001), while adolescents were less likely to meet the AI than children (OR 1.645, p < 0.001 in males and OR 1.625, p < 0.001 in females).Conclusions
A high proportion of children and adolescents are at risk of an inadequate fluid intake. This risk is especially high in males and adolescents when compared with females or children categories. This highlights water intake among young populations as an issue of global concern.68.
69.
Bioenergetics and intermuscular fat in chronic obstructive pulmonary disease‐associated quadriceps weakness 下载免费PDF全文
Pilar Jimenez‐Royo PhD Giulio Gambarota PhD Rahul Dimber MD Nicholas S. Hopkinson PhD Paul M. Matthews MD Andrew P. Brown MSc Michael I. Polkey PhD 《Muscle & nerve》2015,51(2):214-221
Introduction: Chronic obstructive pulmonary disease (COPD) is associated with metabolic abnormalities in muscles of the lower limbs, but it is not known whether these abnormalities are generalized or limited to specific muscle groups, nor is there an easy way of predicting their presence. Methods: Metabolism in the quadriceps and biceps of 14 COPD patients and controls was assessed during sustained contraction using 31‐phosphorus magnetic resonance spectroscopy (31P MRS). T1 MRI was used to measure quadriceps intermuscular adipose tissue (IMAT). Results: COPD patients had prolonged quadriceps phosphocreatine time (patients: 38.8 ± 12.7 s; controls: 25.2 ± 10.6 s; P = 0.006) and a lower pH (patents: 6.88 ± 0.1; controls: 6.99 ± 0.06; P = 0.002). Biceps measures were not significantly different. IMAT was associated with a nadir pH <7.0 (area under the curve = 0.84). Conclusions: Anaerobic metabolism during contraction was characteristic of quadriceps, but not biceps, muscles of patients with COPD and was associated with increased IMAT. Because IMAT can be assessed quickly by conventional MRI, it may be a useful approach for identifying patients with abnormal muscle bioenergetics. Muscle Nerve 51 : 214–221, 2015 相似文献
70.
Luis M. Jara Pilar Cortés Germán Bou Jordi Barbé Jesús Aranda 《Antimicrobial agents and chemotherapy》2015,59(7):4318-4320
The effect of antimicrobials on SOS-mediated mutagenesis induction depends on the bacterial species and the antimicrobial group. In this work, we studied the effect of different families of antimicrobial agents used in clinical therapy against Acinetobacter baumannii in the induction of mutagenesis in this multiresistant Gram-negative pathogen. The data showed that ciprofloxacin and tetracycline induce SOS-mediated mutagenesis, whereas colistin and meropenem, which are extensively used in clinical therapy, do not. 相似文献